Research Articles
An Old Drug's New Trick: Turning Cancer's Survival Signal Into a Death Warrant
Discover how metformin, a common diabetes drug, triggers cancer cell death by activating the ROS-AMPK-ULK1 signaling pathway through AXL mediation in esophageal adenocarcinoma.
The Brain's Plumbing Problem: How a Tiny Molecule Could Clean Up Memory Loss
Discover how Lipoxin A4 methyl ester regulates autophagy and ER stress to combat vascular cognitive impairment and memory loss.
How a Cellular "Switch" Makes Glioblastoma So Aggressive
Discover how the TRIB3 protein acts as a master switch in glioblastoma by restraining autophagy, opening new possibilities for treating this aggressive brain cancer.
The Cellular Short-Circuit: How a Tiny Molecule Commands Cancer Cells to Eat Themselves
Discover how MicroRNA-126 induces autophagy by altering mitochondrial metabolism in malignant mesothelioma, offering new hope for cancer treatment.
The Fragile Powerhouses: Why Mitochondrial Gatekeepers Fail When Cellular Cleanup Stops
Research reveals how autophagy deficiency specifically targets mitochondrial complexes I and II in pancreatic β-cells, leading to metabolic dysfunction and diabetes implications.